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desvenlafaxine will boost the stage or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by nearly 50%; no dosage adjustment wanted with desvenlafaxine doses seven consecutive days straight awa